Protein Details: Cation channel sperm-associated protein 2

Protein ID

ICDB_Pro_1078

Protein Name

Cation channel sperm-associated protein 2

Gene Name

Catsper2

Organism

Rattus norvegicus (Rat)

Length

584 amino acids

AlphaFoldDB

AF-Q6AXP6-F1-model_v4.pdb

Function

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility; a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.

Sequence

MAHERGHLQLPRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPACQKKLMLGDQEQLVRFSIRARRMGHITHAQRLLSRLRVRCGGRPPLSLWAGWVLDSSIFSNFIISLIFLNTFVLMVEIELMNSTNTSLWPLKLALEVTDWFILLSFIVEILLMWLASFFLFWKNAWSVFDFVVTMLSLLPEFVVLIGVSADSVWLQLLRVSRVLRSLKLFARFPQIKVILLALVRALKSMTFLLMLLLIFFYVFAVAGVYFFKEYSRSTIENLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDVWKVPEASRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRNELHEEMTHLEVQYKADIFKRRIIQRRQQSESLRGTSQGKVSEDITETSEATDEEKSEAEESEEEKSEEEKSDVEKSDEEKNDEEKSDEEENDEEKSDVEKSDEEKNDEEKGYTEKVYSGRTFVERSYAERSFAGKAENEKVQKELKEKAYPGSPPNSSSHDEAFAADDTYLENLDWETLVHENLPGLMDMDQDDRVVWPRDSLFRYFELLESLQYNLEERKRLQEFAVQALMNFEDK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1101/gr.2596504; 10.1073/pnas.221454998

RefSeq

NP_001012220.1; XP_008760409.1; XP_017447438.1